Publications by Year

2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013

2024

Current Status for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.

Gallagher KA, Mills JL, Armstrong DG, Conte MS, Kirsner RS, Minc SD, Plutzky J, Southerland K, Tomic-Canic M.

Circulation 2024 Jan 23;149(4):e232-e253. 38095068

circulation

Biofilm-derived oxylipin 10-HOME mediated immune response in women with breast implants.

Bauer TM, Gallagher KA.

J Clin Invest 2024 Feb 1;134(3):e176547. Abstract 38299590

JCI-insight

American Surgical Association Task Force for Research Sustainability. Transforming the Future of Surgeon-Scientists.

Ladner DP, Goldstein AM, Billiar TR, Cameron AM, Carpizo DR, Chu DI, Coopersmith CM, DeMatteo RP, Feng S, Gallagher KA, Gillanders WE. Lal BK, Lipshutz GS, Liu A, Maier RV, Mittendorf EA, Morris AM, Sicklick MA, Velazquez OC, Whitson BA, Wilke LG, Yoon SS, Zeiger MA, Farmer DL, Hwang ES.

Annals of Surgery 2024 Feb 1;279(2):231-239.  37916404

annals-of-surgery

Scavengers in Islets Fuel Diabetic Autoimmunity.

Moon JY, Gallagher KA.

Immunity Cell Press 2024 July 9;57(7):1448-1451. 38986438

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Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling.

Wolf SJ, Audu CO, Moon JY, Joshi AD, Melvin WJ, Barrett EC, Mangum KD, Saldana de Jimenez G, Rocco S, Buckley S, Ahmed Z, Wasikowski R, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Gallagher KA.

Diabetes 2024 June 73(9) doi: 10.2337/db23-0968. 38869447

diabetes

Histone Demethylase JARID1C/KDM5C Regulates TH17 T-cells by Increasing IL-6 Expression in Diabetic Plasmacytoid Dendritic Cells.

Audu CO, Wolf SJ, Joshi AD, Moon JY, Melvin WJ, Sharma SB, Davis FM, Obi AT, Wasikowsji R, Tsoi LC, Barrete EC, Mangum KD, Bauer TM, Kunkel SL, Moore BB, Gallagher KA.

JCI Insight 2024 June 24;9,(12): e172959. 38912581

JCI-insight

2023

Obesity confers macrophage memory.

Mangum KD, Gallagher KA.

Science 2023 Jan 6; 379(6627):28-29. Abstract 36603098

science

Keratinocytes sense and eliminate CRISPR DNA through STING/IFN-k activation and APOBEC3G induction.

Sarkar MK, Uppala R, Zeng C, Billi AC, Tsoi LC, Kidder A, Xing X, Perez White BE, Shao S, Plazyo O, Sirobhushanam S, Xing E, Jiang Y, Gallagher KA, Voorhees JJ, Kahenberg JM, Gudjonsson JE.

J Clin Invest 2023 May;133(9):e159393. 36928117

JCI-insight

The Histone Methyltransferase Setdb2 Modulates TIMP-MMP Activity During Abdominal Aortic Aneurysm Development.

Davis FM, Melvin WJ, Mangum K, Tsoi LC, Wasikowski R, Joshi A, Kunkel SL, Gudjonsson JE, Gallagher KA.

Annals of Surgery. 2023 Sept 1;278(3):426-440. 37325923

annals-of-surgery

2022

Single cell transcriptomics reveals dynamic role of smooth muscle cells and enrichment of immune cell subsets in human abdominal aortic aneurysms.

Davis, FM, Gallagher KA.

Annals of Surgery 2022 Sept 1;276(3):511-521. 35762613

annals-of-surgery

IFNk is critical for normal wound repair and is decreased in diabetic wounds.

Wolf S, Audu CO, Joshi AD, denDekker AD, Melvin WJ, Davis FM, Xing X, Wasikowski R, Tsoi LC, Kunkel SL, Gudjonsson JE, O’Riordan MX, Kahlenberg JM, Gallagher KA.

JCI Insight 2022 May;7(9):e/52765. 35358091

JCI-insight

Macrophage-specific inhibition of the histone demethylase JMJD3 decreases STING and pathologic inflammation in diabetic wound repair.

Audu CO, Melvin WJ, Joshi A, Wolf S, Moon JY, Davis FM, Barrett EC, Mangum K, Deng H, Xing X, Wasikowski R, Tsoi LC, Sharma SB, Bauer TM, Shadiow J, Corriere MA, Obi AT, Kunkel SL, Levi BS, Moore BB, Gudjonsson JE, Smith, AM, Gallagher KA.

Cellular and Molecular Immunology 2022 Nov; 19(11):1251-1262. 361277466

ProBiologists

The Histone Methyltransferase MLL1/KMT2A in Monocytes Drives Coronavirus-Associated Coagulopathy and Inflammation.

Sharma SB, Melvin WJ, Audu CO, Bame M, Rhoads NM, Wu W, Kanthi Y, Knight J, Adili R, Holinstat M, Wakefield TW, Henke P, Moore BB, Gallagher KA, Obi AT.

Blood 2022 Dec 9;blood.2022015917.  doi: 10.1182/blood.2022015917. 36493338

blood-logo

Macrophage-mediated PDGF activation correlates with regenerative outcomes following musculoskeletal trauma.

Chowdary A, Maerz T, Henn D, Hankenson K, Pagan C, Marini S, Gallagher KA, Aguilar C, Tower R, Levi BS.

Annals of Surgery 2022 Sept 15; doi:10.1097/SLA0000000000005704. 36111847

annals-of-surgery

Multi-ancestry GWAS deciphers genetic architecture of abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.

Roychowdhury T, Klarin D, Levin MG, et al.

MedRxiv May 2022. Doi.org/10.1101/2022.05.27.22275607

medRxiv_homepage_logo

The Role of Epigenetic Modifications in Abdominal Aortic Aneurysm Pathogenesis.

Mangum KD, Gallagher KA, Davis FM.

2022 Jan; 21(2): 172. Biomolecules. 35204673

Biomolecules

Dextran-Mimetic Quantum Dots for Multimodal Macrophage Imaging In Vivo, Ex Vivo, and In Situ.

Deng H, Konopka CJ, Pabhu S, Sarkar S, Medina NG, Fayyaz M, Gamage HEV, Shahoei SH, Nall D, Youn Y, Dobrucka IT, Audu CO, Joshi A, Melvin WJ, Gallagher KA, Selvin PR, Nelson ER, Dobrucki LW, Swanson KS, Smith AM.

ACS Nano 2022 January. Doi.org/10.1021/acsnano.1c07010. 35107994

ADS-NANO

2021

Macrophage-Mediated Inflammation in Diabetic Wound Repair.

Wolf SJ, Melvin WJ, Gallagher KA.

Review Article, Seminars in Cell and Developmental Biology 2021 June 25;S1084-9521(21)00164-6, doi:10.1016/jsemcdb.2021.06.013. 34183242

Coronavirus induces diabetic macrophage-mediated inflammation via SETDB2.

Melvin WJ, Audu CO, Davis FM, Sharma SB, Joshi A, denDekker AD, Wolf S, Barrett E, Mangum K, Zhou X, Bame M, Ruan A, Obi, AT, Kunkel SL, Moore BB, Gallagher KA.

PNAS. 2021. Sept 21;118(38):e2101071118. 34479991

PNAS

Inhibition of macrophage histone demethylase JMJD3 protects against abdominal aortic aneurysms.

Davis FM, Tsoi LC, Melvin WJ, denDekker AD, Wasikowski R, Joshi AD, Wolf S, Obi AT, Billi AC, Xing X, Audu CO, Moore BB, Kunkel SL, Daugherty A, Lu HS Gudjonsson JE, Gallagher KA.

JExpMed 2021 June 7;218(6). doi.org/10.1084/j:2021. 33779682.

Journal-Experimental-Medicine

2020

Epigenetic Regulation of the PGE2 Pathway Modulates Macrophage Phenotype in Normal and Pathologic Wound Repair.

Davis FM, Tsoi LC, Wasikowski R, denDekker A, Joshi A, Wilke C, Deng H, Wolf SJ, Obi AT, Huang S, Billi AC, Robinson S, Lipinski J, Melvin WJ, Audu CO, Weidinger S, Kunkel SL, Smith A, Gudjonsson JE, Moore BB, Gallagher KA.

JCI Insight. 5(17): e138443, Sept 2020. https://doi.org/10. 1172/jci.insight. 32879137

JCI-insight

Ly6CLo Monocyte/Macrophages are Essential for Thrombus Resolution in a Murine Model of Venous Thrombosis.

Obi AT, Kimball AS, Dowling A, Cai Q, Adili R, Jank H, Jaffer J, Schaller M, Henke PK, Kunkel S, Gallagher KA.

Thromb Haemost 120(2):289-299, Aug 1, 2020. 31887775

JTH-logo

Palmitate-TLR4 Signaling Regulates the Histone Demethylase, JMJD3, in Macrophages and Impairs Diabetic Wound Healing.

Davis FM, denDekker A, Joshi A, Wolf SJ, Audu CO, Melvin WJ, Mangum K, O’Riordan M, Kinkel SL, Gallagher KA.

European Journal of Immunology. 2020 Jul 14, doi: 10.1002/eji.202048651. 32662520

European

Epigenetic Regulation of TLR4 in Diabetic Macrophages Modulates Immunometabolism and Wound Repair.

Davis FM, denDekker A, Kimball A, Joshi A, El Azzouny M, Obi AT, Lipinski J, Gudjonsson JE, Xing X, Audu C, Melvin W, Singer K, Henke PK, Moore BB, Burant C, Kunkel SL, Gallagher KA.

The Journal of Immunology 2020 May1;204(9):2503-2513, 2020. 32205424

Journal-Immunology

TNFα Regulates Diabetic Macrophage Function through the Histone Acetyl-transferase, MOF.

denDekker A, Davis FM, Joshi A, Allen R, Lipinski J, Wolf SJ, Nycz D, Bermick J, Moore BB, Gudjonsson JE, Kunkel SL, Gallagher KA.

JCI Insight 5(5):e132306, Mar 2020. 32069267

JCI-insight

Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing.

Sorkin M, Huber AK, Hwang C, Carson WF 4th, Menon R, Li J, Vasquez K, Pagani C, Patel N, Li S, Visser ND, Niknafs Y, Loder S, Scola M, Nycz D, Gallagher KA, McCauley LK, Xu J, James AW, Agarwal S, Kunkel S, Mishina Y, Levi B.

Nature Communications 11(1): 722,Feb 2020. 32024825

Nature_Communications_Logo

2019

Research highlighted as a featured "Preview" article: Diabetes Impedes the Epigenetic Switch of Macrophages into Repair Mode.

Gallagher KA.

Immunity 51(2): 199-201, 2019. 31433963

Immunity

Sepsis Induces Prolonged Epigenetic Modifications in Bone Marrow and Peripheral Macrophages Impairing Inflammation and Wound Healing.

Davis FM, Schaller M, denDekker A, Joshi A, Kimball A, Evanoff H, Wilke C, Cavassani K, Scola M, Carson B, Moser S, Blanc V, Engoren M, Moore BB, Kunkel KL, Gallagher KA.

Arterioscler Thromb Vasc Biol 39(11): 2353-2366, 2019. 31644352

atvb-logo

The Histone Methyltransferase, Setdb2, Modulates Macrophage Phenotype and Uric Acid Production in Normal and Diabetic Wound Repair.

Kimball AS, Davis FM, denDekker A, Joshi A, Schaller M, Bermick J, Burant C, Obi A, Nycz D. Robinson S, Allen R, Lukacs N, Henke PK, Moore BB, Kunkel SL, Gallagher KA.

Immunity 51(2): 258-271, 2019. 31350176

Immunity

Sirt3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair.

Boniakowski A, denDekker A, Davis FM, Joshi A, Kimball AS, Schaller M, Allen R, Bermick J, Nycz D, Skinner M, Robinson S, Obi A, Moore B, Gudjonsson JE, Lombard D, Kunkel S, Gallagher KA.

Journal of Investigative Dermatology 139(12):2528-2537.e2, 2019. 31207226

JID

Epigenetic Mechanisms in Monocyte/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease.

Davis FM, Gallagher KA.

Arteriosclerosis Thrombosis Vascular Biology 39(4): 623-634, 2019. 30760015

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Histone Methylation Directs Myeloid Toll-like Receptor 4 Expression and Regulates Wound Healing Following Cutaneous Tissue Injury.

Davis FM, denDekker A, Kimball A, Joshi A, Obi A, Singe S, Henke P, Moore B, Kunkel S, Gallagher KA.

The Journal of Immunology 202(6): 1777-1785, 2019. 30710046

Journal-Immunology

Targeting epigenetic mechanisms in diabetic wound healing.

denDekker A, Davis FM, Kunkel SL, Gallagher, KA.

Translational Research 204: 39-50, 2019. 30392877

TRI

Chorioamnionitis exposure remodels the unique histone modification landscape of neonatal monocytes and alters the expression of immune pathway genes.

Bermick J, Gallagher KA, denDekker A, Kunkel S, Lukacs N, Schaller M.

FEBS J. 286(1): 82-109, 2019. 30565411

FEBS

2018

Macrophage chemokine receptor CCR2 plays a crucial role in macrophage recruitment and regulated inflammation in wound healing.

Boniakowski AE, Kimball AS, Joshi A, Schaller M, Davis FM, denDekker A, Moore B, Kunkel SL, Gallagher KA.

European Journal of Immunology 48(9): 1445-1455, 2018. 29879295

European

Ly6CHi Blood Monocyte/Macrophage Drive Chronic Inflammation and Impair Wound Healing in Diabetes Mellitus.

Kimball AS, Schaller M, Joshi A, Davis FM, denDekker A, Boniakowski AE, Bermick J, Obi AT, Moore B, Henke PK, Kunkel S, Gallagher KA.

Arteriosclerosis, Thrombosis, and Vascular Biology Journal 38(5): 1102-1114, 2018. 29496661

atvb-logo

Dysfunctional Wound Healing in Diabetic Foot Ulcers.

Davis FM, Kimball AS, Boniakowski A, Gallagher KA.

New Crossroads Current Diabetes Reports: Microvascular Complications - Neuropathy 18(2): 1-8, 2018. 29362914

2017

The Histone Methyltransferase, MLL1, Directs Macrophage- Mediated Inflammation in Wound Healing and is Altered in a Murine Model of Obesity and Type 2 Diabetes.

Kimball A, Joshi A, Carson WF, Boniakowski A, Schaller M, Allen R, Bermick J, Henke PK, Davis, F, Burant CF, Kunkel SL, Gallagher KA.

Diabetes 66(9): 2459-2471, 2017. 28663191

diabetes

Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing.

Boniakowski A, Kimball A, Jacobs B, Kunkel SL, Gallagher KA.

The Journal of Immunology 199(1): 17-24, 2017. 28630109

Journal-Immunology

Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing.

Kimball A, Joshi A, Boniakowski A, Schaller M, Chung J, Allen R, Bermick J, Henke PK, Burant CF, Kunkel SL, Gallagher KA.

Frontiers in Immunology 1(8): 635, 2017. 28620387

frontiers-in-immunology-workshop

The STAT4/MLL1 Epigenetic Axis Regulates the Antimicrobial Functions of Murine Macrophages.

Carson WF 4th, Cavassani KA, Soares EM, Hirai S, Kittan NA, Schaller MA, Scola MM, Joshi A, Matsukawa A, Aronoff DM, Johnson CN, Dou Y, Gallagher KA, Kunkel SL.

Journal of Immunology 199(5): 1865-1874, 2017. 28733487

Journal-Immunology

IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis.

Mehta NN, Teague HL, Swindell WR, Baumer Y, Ward NL, Xing X, Baugous B, Johnston A, Joshi AA, Silverman J, Barnes DH, Wolterink L, Nair RP, Stuart PE, Playford M, Voorhees JJ, Sarkar MK, Elder JT, Gallagher KA, Ganesh SK, Gudjonsson JE.

Sci Rep 7(1): 13831, 2017. PM29062018/PMC5653789

sci-rep

Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1/2 phosphatase Dusp6.

Carson WF IV, Salter- Green SE, Joshi A, Gallagher KA, Kunkel SL.

Cellular Immunology 314: 63-7, 2017. 28242024

ProBiologists

2016

Alterations in macrophage phenotypes in experimental venous thrombosis.

Gallagher KA, Obi AT, Elfline MA, Hogikyan D, Luke CE, Henke SP, Oostra C, Comerota AJ, Coleman D, Henke PK.

Journal of Vascular Surgery Venous & Lymphatic Disorders 4(4): 463-71, 2016. 27639001

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Inflammation as a Therapeutic Target for Diabetic Neuropathies.

Pop-busui R, Ang L, Holmes C, Gallagher KA, Feldman E

Current Diabetes Reports 16(3): 1-10, 2016. 26897744

15344827

2015

Research highlighted as a featured article: Epigenetic changes lead to impaired wound healing in patients with T2DM.

Gallagher KA.

Nature Reviews Endocrinology 11: 65, 2015. 25421373

nrendo-logo-sq

2014

Epigenetic Changes in Bone Marrow Progenitor Cells Influence the Inflammatory Phenotype and Alter Wound Healing in Type 2 Diabetes.

Gallagher KA, Joshi A, Carson WF, Schaller M, Allen R, Mukerjee S, Kittan N, Feldman EL, Henke PK, Hogaboam C, Burant CF, and Kunkel SL.

Diabetes 60(4): 1420-30, 2014. 25368099

diabetes

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction.

Cawthorn WP, Scheller EL, Learman BS, Parlee SD, Simon BR, Mori H, Ning X, Bree AJ, Schell B, Broome DT, Soliman SS, DelProposto JL, Lumeng CN, Mitra A, Pandit SV, Gallagher KA, Miller JD, Krishnan V, Hui SK, Bredella MA, Pouneh K. Fazeli, Klibanski A, Horowitz MC, Rosen CJ, MacDougald OA.

Cell Metabolism 20: 1-8, 2014. 24998914

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2013

Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes.

Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, Carson IV WF, Mukhergee S, Grembecka J, Cierpicki T, Jarai G, Westwick J, Kunkel SL, Hogaboam C.

PLoS ONE 8: E78045, 2013. 24205083

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Artificial Sweeteners Stimulate Adipogenesis and Suppress Lipolysis Independent of Sweet Taste Receptors

Simon BR, Parlee SD, Learman BS, Mori H, Scheller EL, Cawthorn WP, Ning X, Gallagher KA, Tyrberg B, Assadi-Porter FM, Evans CR, Macdougald OA.

J Biol Chem 288: 32475-89, 2013. 24068707

journal-of-biological-chemistry-jbc-logo-vector